He practiced in the District of Columbia and Maryland for a while, and he joined the National Health Service Corps in 1995. They assigned him to Mobile, AL, his hometown, where he practiced dentistry at Franklin Primary Health Center for seven years.
In December 2001, Dr. Little opened his private practice in the former site of Dr. Robert Gilliard's 40-year dental practice at 712 South Washington Avenue in Mobile. In time, he moved the practice to its current location at 1020 Montlimar Dr.
In addition to operating a family dental practice that serves young and old alike in Mobile and the surrounding areas, he continues to provide dental services to residents of the Albert P. Brewer Center.